diff --git a/.github/scripts/docker-compose.yml b/.github/scripts/docker-compose.yml
new file mode 100644
index 0000000000..eb2caaeed9
--- /dev/null
+++ b/.github/scripts/docker-compose.yml
@@ -0,0 +1,19 @@
+version: '3.8'
+
+services:
+  mysql:
+    image: mysql:8.0.35
+    container_name: ghost-mysql
+    ports:
+      - "3306:3306"
+    environment:
+      MYSQL_ROOT_PASSWORD: root
+      MYSQL_DATABASE: ghost
+    restart: always
+    volumes:
+      # Turns out you can drop .sql or .sql.gz files in here, cool!
+      - ./mysql-preload:/docker-entrypoint-initdb.d
+    healthcheck:
+      test: "mysql -uroot -proot ghost -e 'select 1'"
+      interval: 1s
+      retries: 120
diff --git a/.github/scripts/mysql-preload/.keep b/.github/scripts/mysql-preload/.keep
new file mode 100644
index 0000000000..e69de29bb2
diff --git a/.github/scripts/setup.js b/.github/scripts/setup.js
new file mode 100644
index 0000000000..59fd37b3b5
--- /dev/null
+++ b/.github/scripts/setup.js
@@ -0,0 +1,94 @@
+const {spawn} = require('child_process');
+const fs = require('fs').promises;
+const path = require('path');
+
+const chalk = require('chalk');
+
+/**
+ * Run a command and stream output to the console
+ *
+ * @param {string} command
+ * @param {string[]} args
+ * @param {object} options
+ */
+async function runAndStream(command, args, options) {
+    return new Promise((resolve, reject) => {
+        const child = spawn(command, args, {
+            stdio: 'inherit',
+            ...options
+        });
+
+        child.on('close', (code) => {
+            if (code === 0) {
+                resolve(code);
+            } else {
+                reject(new Error(`'${command} ${args.join(' ')}' exited with code ${code}`));
+            }
+        });
+
+    });
+}
+
+(async () => {
+    if (process.env.NODE_ENV !== 'development') {
+        console.log(chalk.yellow(`NODE_ENV is not development, skipping setup`));
+        return;
+    }
+
+    const coreFolder = path.join(__dirname, '../../ghost/core');
+    const config = require('../../ghost/core/core/shared/config/loader').loadNconf({
+        customConfigPath: coreFolder
+    });
+
+    const dbClient = config.get('database:client');
+
+    if (!dbClient.includes('mysql')) {
+        let mysqlSetup = false;
+        console.log(chalk.blue(`Attempting to setup MySQL via Docker`));
+        try {
+            await runAndStream('yarn', ['docker:reset'], {cwd: path.join(__dirname, '../../')});
+            mysqlSetup = true;
+        } catch (err) {
+            console.error(chalk.red('Failed to run MySQL Docker container'), err);
+            console.error(chalk.red('Hint: is Docker installed and running?'));
+        }
+
+        if (mysqlSetup) {
+            console.log(chalk.blue(`Adding MySQL credentials to config.local.json`));
+            const currentConfigPath = path.join(coreFolder, 'config.local.json');
+
+            let currentConfig;
+            try {
+                currentConfig = require(currentConfigPath);
+            } catch (err) {
+                currentConfig = {};
+            }
+
+            currentConfig.database = {
+                client: 'mysql',
+                connection: {
+                    host: '127.0.0.1',
+                    user: 'root',
+                    password: 'root',
+                    database: 'ghost'
+                }
+            };
+
+            try {
+                await fs.writeFile(currentConfigPath, JSON.stringify(currentConfig, null, 4));
+            } catch (err) {
+                console.error(chalk.red('Failed to write config.local.json'), err);
+                console.log(chalk.yellow(`Please add the following to config.local.json:\n`), JSON.stringify(currentConfig, null, 4));
+                process.exit(1);
+            }
+
+            console.log(chalk.blue(`Running knex-migrator init`));
+            await runAndStream('yarn', ['knex-migrator', 'init'], {cwd: coreFolder});
+
+            //console.log(chalk.blue(`Running data generator`));
+            //await runAndStream('node', ['index.js', 'generate-data'], {cwd: coreFolder});
+        }
+    } else {
+        console.log(chalk.green(`MySQL already configured, skipping setup`));
+    }
+})();
diff --git a/package.json b/package.json
index a4a986bedc..3f8b7f6848 100644
--- a/package.json
+++ b/package.json
@@ -29,7 +29,8 @@
     "dev": "node .github/scripts/dev.js",
     "fix": "yarn cache clean && rm -rf node_modules && yarn",
     "knex-migrator": "yarn workspace ghost run knex-migrator",
-    "setup": "yarn && git submodule update --init",
+    "setup": "yarn && git submodule update --init && NODE_ENV=development node .github/scripts/setup.js",
+    "docker:reset": "docker-compose -f .github/scripts/docker-compose.yml down -v && docker-compose -f .github/scripts/docker-compose.yml up -d --wait",
     "lint": "nx run-many -t lint",
     "test": "nx run-many -t test",
     "test:unit": "nx run-many -t test:unit",